Autoimmune Hepatitis

Autoimmune hepatitis is a chronic liver disease in which the body's immune system mistakenly attacks liver cells, leading to inflammation and potential liver damage. If left untreated, AIH can progress to liver fibrosis, cirrhosis, and even liver failure. Early diagnosis and treatment are crucial for managing the disease effectively.

The exact cause of autoimmune hepatitis (AIH) is not fully understood, but it is believed to be a combination of genetic predisposition and environmental triggers such as exposure to certain viruses or toxins triggering the immune response. Also, individuals with autoimmune conditions like type 1 diabetes, thyroid disorders, or rheumatoid arthritis are at higher risk.

Symptoms of autoimmune hepatitis can vary from mild to severe and may include:

Fatigue and general weakness
Jaundice (yellowing of the skin and eyes)
Abdominal discomfort, especially in the upper right side
Nausea and loss of appetite
Dark urine and pale stools
Joint pain
Unexplained weight loss.

Diagnosing autoimmune hepatitis involves a combination of clinical evaluation, laboratory tests, and imaging studies:

Blood tests to check liver enzyme levels and the presence of specific autoantibodies.
Liver biopsy. A sample of liver tissue may be analyzed to confirm inflammation and assess the extent of liver damage.
Imaging studies. Ultrasound, MRI, or CT scans may help rule out other liver diseases.

While there is no cure for autoimmune hepatitis, treatment focuses on reducing immune system activity and preventing further liver damage:

Corticosteroids to reduce liver inflammation.
Immunosuppressive medications to help control the immune response.
Regular monitoring. Patients require ongoing medical supervision to assess liver function and medication effectiveness.
Liver transplantation. In cases of severe liver failure, a liver transplant may be necessary.

At Karolinska University Hospital, our experienced team can provide comprehensive diagnosis, treatment, and rehabilitation.

Gastroenterology

Gastroenterology includes both upper abdominal surgery and lower abdominal surgery Gastroenterology

Liver Transplant

Karolinska University Hospital runs one of the more extensive liver surgery units in the Nordics, and has a special assignment for liver transplants on behalf of the Swedish National Board of Health and Welfare. Both children and adults undergo transplants with excellent results at Karolinska. Liver Transplant

Center

Transplantation Center

We aim to significantly improve the quality of life for a vast number of patients with various diseases, as well as give new life to those for whom there is no other treatment.