Karolinska Institutet and Karolinska University Hospital strengthen their commitment in advanced cell, gene and tissue therapies
Karolinska ATMP center
Internationally, these therapies are also referred to as "Advanced Therapy Medicinal Products" (ATMP). The new center, which operates in both Huddinge/Flemingsberg and Solna, will be named Karolinska ATMP Center. The major advances in research and development of advanced medicines in the field of cell and gene therapy have the potential to treat and cure diseases that could not have been cured by traditional medicines.
We already see examples of gene therapy drastically improving the survival of patients with certain types of cancers. Advances in ATMP and other precision medicine will change the way healthcare is conducted. We must increase the pace of introducing the new treatments, to cure more people but also to make socio-economic gains, says Björn Zoëga, hospital director at Karolinska University Hospital.
Karolinska Institutet and Karolinska University Hospital are together among the European leaders in advanced cell and gene therapy regarding research, manufacturing and treatment. The Department of Cell Therapy and Allogeneic Stem Cell Transplantation (CAST) was one of the first of its kind in Europe when founded in 1975 in Huddinge.
CAST and the affiliated areas of transfusion medicine and pediatrics are JACIE-accredited, which is the Europe’s official accreditation body in the field of haematopoietic stem cell transplantation and cellular therapy.
Sophia Borate, postdoctoral researcher at Karolinska Institutet’s research group for cell- and gene therapy at campus Flemingsberg.
The department performs blood stem cell transplantation and advanced cellular therapy in both pediatric and adult patients with aplastic anemia, autoimmune diseases, inborn genetic errors, hemoglobinopathies, MDS, leukemia, lymphoma, myeloma and even certain solid tumors. Sweden's first standard treatment with CAR-T cells was performed here in 2019 reflecting the ongoing paradigm shift towards more and more patients being treated with ATMPs in both standard of care and clinical trials.
Swedish gene therapy advancements
Sweden’s first gene therapy drug for clinical trials was produced 1997 under Good Manufacturing Practice (GMP) at Vecura as part of Karolinska Center for Cell Therapy (KCC) in Huddinge. Here, the first CAR-T cells that went into a clinical trial in Europe were produced as early as 2014. Today Vecura consists in 13 clean rooms and there is a further GMP facility with a special focus on immunotherapy located at Karolinska Comprehensive Cancer Center (KCCC) in Solna.
Matti Sällberg, professor of biomedical analytics at Karolinska Institutet and responsible for the pre-GMP facility.
The Nordic’s first pre-GMP unit was inaugurated at Karolinska Institutet’s Campus Flemingsberg in 2019 including five clean rooms. This pre-GMP unit is an important bridge between research laboratories and Vecura and has already been instrumental in the development of two therapeutic products that are currently tested in clinical trials.
The Nordic’s first pre-GMP unit was inaugurated at Karolinska Institutet’s Campus Flemingsberg in 2019 including five clean rooms. This pre-GMP unit is an important bridge between research laboratories and Vecura and has already been instrumental in the development of two therapeutic products that are currently tested in clinical trials.
Transforming healthcare
– The paradigm shift taking place in healthcare today is about medical research finding solutions in healthcare with the help of new technological achievements. The establishment of the Karolinska ATMP Center aims to do that, by strengthening collaboration between research and clinic, we will speed up the application of research for the implementation of new gene, cell and tissue therapies that help the patient, says Annika Östman Wernerson, president at Karolinska Institutet.
– Together with our industry partners, other regions and universities around the world, Karolinska ATMP Center can make important contributions to the development of new ATMP therapies, concludes Annika Östman Wernerson.
The Karolinska ATMP Center will be funded in equal shares by Karolinska University Hospital and Karolinska Institutet. The center will gather the development of cell, gene and tissue therapy in one organization, and it will participate in national and international collaborations. This will strengthen the collaboration with neighboring regions and pharmaceutical companies.
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For further information, please contact:
- Karolinska University Hospital Press Office at presstjanst.karolinska@regionstockholm.se.
- Karolinska Institutet Press Office at pressinfo@ki.se.
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Photos: Joakim Lindberg.